Programmable probiotic strains provide localized, sustained delivery of GLP-1 agonists, pro-insulin, and IL-10 for a new era of precision microbial medicines.
Recombinant live biotherapeutics represent a transformative advancement in precision therapeutics. Our technology enables targeted chromosome-level engineering of probiotic strains to synthesize and locally deliver key therapeutic molecules—GLP-1 receptor agonists, pro-insulin, and IL-10—directly within the human colon. By harnessing the natural advantages of the gut microbiome, this platform provides controlled, site-specific, and sustained biologic delivery, opening new possibilities for treating metabolic and inflammatory diseases with enhanced safety and efficacy. We aim to redefine biologic therapy through programmable, responsive, and clinically scalable microbial medicines built for the future of healthcare.
(i) Department of Biotechnology, Govt. of India (ii) Biotechnology Industry Research Assistance Council (iii) Blockchain for Impact (BFI) (iv) Bill & Melinda Gates Foundation (v) Wellcome Trust, UK
This intellectual property involves engineering bacteria for stable therapeutic peptide production, developing genetic tools for bacterial genome engineering, and using integrative expression vectors. The broad technology focuses on genetic engineering and the development of tools and methods for manipulating bacterial genomes, primarily for producing therapeutic peptides.
Fellow of the National Academy of Sciences (2024). S. Ramachandran-National Bioscience Award, Department of Biotechnology, Govt. of India (2023). Fellow of West Bengal Academy of Science and Technology (2022). Young Scientist Award, International Life Sciences Institute (2021). Japan Society for the Promotion of Science Fellowship, Govt. of Japan (2017). Young Investigator Award, Yakult India Microbiota and Probiotic Science Foundation (2016). CNRS-Post-Doctoral Research Fellow, Govt. of France (2008).
Dr. Bhabatosh Das, Professor at THSTI, and Dr. Dinesh Mahajan, Associate Professor at THSTI, form the core team.
Professor
Associate Professor
