Chicken Egg as Next-Generation Bioreactor System
RISPR-Modified Chicken PGCs for High-Yield Recombinant Protein Production. Revolutionizing protein production with avian biotechnology - producing valuable biologics at a fraction of current costs.
CRISPR-modified Chicken PGCs: A High-Yield Egg Bioreactor System for Recombinant Protein Production
Filed Indian Provisional Patent Application No. 202131001733 titled “PGC Conservation of Indian Aseel and Kadaknath Chickens via Single-Host Double Chimera Technology,” invented by Dr. Adnan Naim, Dr. S. K. Mishra, and Dr. D. Nayak.
The platform uses CRISPR to design and deliver Cas9 and guide RNA into chicken cells via viral vectors, transfection, or microinjection, enabling precise gene editing and knock-in generation through donor template–guided DNA repair. Edited germ cells are introduced into embryos to produce chickens that lay eggs containing targeted recombinant proteins, creating a simple, scalable bioreactor system for biologics production.
Assoicate Professor
Scientist
Biotechnologist
